C0378

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C0378

Sigma

 

Chloramphenicol

≥98% (TLC)

Synonym:Chloromycetin®, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol
CAS Number:56-75-7
Linear Formula:Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
Molecular Weight:323.13
Beilstein Registry Number:2225532
EC Number:200-287-4
MDL number:MFCD00078159
PubChem Substance ID:24892250

Details

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Description

Biochem/physiol ActionsMode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.
Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).
Legal InformationChloromycetin is a registered trademark of Parke-Davis & Co.

Properties

assay≥98% (TLC)
mp148-150 °C(lit.)
Gene Informationhuman ... CYP1A2(1544)

Safety

Personal Protective EquipmentEyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard CodesT
Risk Statements45
Safety Statements53-45
WGK Germany3
RTECSAB6825000

References

MerckMerck 13,2087
BeilsteinBeil. 13,IV,2742
referenceAldrich MSDS 1, 364:D / Corp MSDS 1 (1), 722:C / FT-IR 2 (2), 2987:A / FT-IR 1 (2), 362:D / FT-NMR 1 (2), 1380:A / IR-Spectra (3), 1074:A / IR-Spectra (2), 939:D / NMR-Reference 2 (2), 340:B / RegBook 1 (2), 2011:G / Sax 6, 668 / Sigma FT-IR 1 (1), 634:C / Structure Index 1, 321:A:2